Affinity Chromatography

CHROMATOGRAPHIC RESINS

Our mechanically resistant methacrylic resins are the solution for the issues correlated to the industrial use of traditional soft gel media. Compressible resins perform well in the small scale, but impose severe limits on bed heights and flow rates. Nowadays, industrial processes move towards rigid resins, suitable for big chromatography scale and high flow rates, making easier time and productivity optimization. Our products represent the answer to this industrial requirements.
SPRIN affinity and chiral chromatography media are designed to display high Dynamic Binding Capacity (DBC) and many cycles of resin reuse. High DBC lowers consumables cost, impacting significantly on product cost, while resin reuse is a dominant parameter at high scales. Recycling reduces material cost and column packing frequency.

ACTIVATED SUPPORTS FOR LIGAND IMMOBILISATION

Products are characterized by:
• chemically stable and not degradable polymeric structure;
• high bulk density for controlled bed expansion and settlement;
• high functional group stability in acids, alkali and solvents;
• lower beads compressibility under high flow rate and high column bed size conditions;
• high mechanosmotic resistance, associated to negligible beads volume change under pH, salt concentration and solvents variation.

For technical information see: SEPABEADS FP and EB typical features

SERVICES

Computer Aided Rational design of specific ligands for affinity, or chiral chromatography
Development of immobilization process onto the most appropriate solid support for specific applications

COMING SOON

Antibody purification materials:
• Stable and reusable resins for non-specific antibody affinity purification from serum and other fluids
• Kit for peptide ligand immobilization, for custom-made affinity resins for purification of antibodies and other molecules of interest