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SynbeadsTM: Hydrophilic Rigid Resins for Solid Phase Peptide Synthesis

 

 

Oligobeads for Oligonucleotide Synthesis

 

 

 

 

SYNBEADS CHARACTERISTICS

 

Hydrophilic Resins for Solid Phase Organic Synthesis
- rigid and non-swelling
- highly porous (200 to 250 nm)
- methacrylate functionalized, hydrophilic
- polymer beads with perfect spherical form
- very high physico-chemical stability
- calibrated functional group density

 

 

   

 

 

The HIGH POROSITY of Synbeads with an average pore radius of 200 to 250 nm:
- Guarantees optimal diffusion of reagents and solvents and uniform reactivity within the bead.
- Improves mass transfer for high yield, high purity and high reproducibility

 

 CHEMICAL AND PHYSICAL STABILITY:
- LiAlH4 in THF (saturated solution), reflux, overnight;
- HCl 12N, room temperature, overnight;
- NaOH 1N reflux, overnight;
- Toluene, reflux, 48h;
- TFA (Trifluoroacetic acid) room temperature, 2 weeks;
- Piperidine (solution of 20% in DMF), room temperature, 48h.
- Mechanical and mechano-osmotical stress
- Microwave (100°C, 20min, 75W) and thermal stress

The NEGLEGIBLE SWELLING assures a constant bead volume during all operations

  • at Laboratory
  • in Peptide Synthesizers
  • at Production Bulk Scale

 

The possibility to recycle the polymer after each synthetic step offers a great advantage to decrease the overall process cost in solid phase applications

 

For technical information see: Typical features of SYNBEADS 

 

 

SYNBEADS PRODUCT LIST

 

Standard Polymers

 

Code Name Qty Price
1A3102 A310 Synbeads
Aminomethyl-methacrylate
150-300 μm, 0.7-1.0 mmol/gdry		 25g
100g
1Kg		 55,-
160,-
850,-
1C3102 C310 Synbeads
Chloromethyl-methacrylate
150-300 µm, 0.4-0.6 mmol/gdry 		 25g
100g
1Kg		 60,-
170,-
900,-
1B3102 B310 Synbeads
Bromomethyl-methacrylate
150-300 µm, 0.4-0.6 mmol/gdry 		 25g
100g
1Kg		 220,-
660,-
3500,-
1H3102 H310 Synbeads
Hydroxymethyl-Methacrylate
150-300 µm, 0.2-0.4 mmol/gdry 		 25g
100g
1Kg		 115,-
340,-
1800,-
1X3102 X310 Synbeads
Carboxyl-Methacrylate
150-300 µm, 0.2-0.4 mmol/gdry 		 25g
100g
1Kg		 220,-
660,-
3500,-

 net prices in EUR, VAT excluded

 

 

Preloaded Polymers

 

Code Name Qty Price
1WLKC2B HMPA-Synbeads
p-Hydroxymethylphenoxy acetic amide (Wang linker)
150-300 µm, 0.2-0.4 mmol/gdry		 5g
25g
100g		 125,-
500,-
1500,-
1MPBC2B HMPB-Synbeads
4-(4-Hydroxymethyl-3-methoxyphenoxy)-butanoyl amide
150-300 µm, 0.2-0.4 mmol/gdry		 5g
25g
100g		 125,-
500,-
1500,-
1BRAC2B

Bromoacetal-Synbeads
2-Bromo-1-ethoxyethan-1-oxy
Suitable for multifunctional heterocyclics synthesis using a N-acyliminium ion cyclisation
150-300 µm, 0.2-0.4 mmol/gdry

 5g
25g
100g		 80,-
320,-
950,-

 net prices in EUR, VAT excluded

 

  

Fmoc-AA-Wang Synbeads

 

Code Name Qty Price
1WLKC2BA Fmoc-Ala-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1WLKC2BR-B

Fmoc-Arg(Pbf)-Wang Synbeads

150-300 µm, 0.1-0.4 mmol/g

 5g
25g		 390,-
1500,-
1WLKC2BN Fmoc-Asn(Trt)-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 210,-
850,-
1WLKC2BD
 		 Fmoc-Asp(OtBu)-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 170,-
670,-
1WLKC2BC-B
 		 Fmoc-Cys(Trt)-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g

250,-

1000,- 
1WLKC2BE
 		 Fmoc-Glu(OtBu)-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 170,-
670,-
1WLKC2BQ
 		 Fmoc-Gln(Trt)-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 250,-
1000,-
1WLKC2BG
 		 Fmoc-Gly-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1WLKC2BH Fmoc-His(Trt)-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 185,-
750,-
1WLKC2BI Fmoc-Ile-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1WLKC2BL Fmoc-Leu-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1WLKC2BK Fmoc-Lys(Boc)-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 170,-
670,-
1WLKC2BM Fmoc-Met-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1WLKC2BF Fmoc-Phe-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1WLKC2BP Fmoc-Pro-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1WLKC2BS Fmoc-Ser(tBu)-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 170,-
670,-
1WLKC2BT Fmoc-Thr(tBu)-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 170,-
670,-
1WLKC2BW Fmoc-Trp(Boc)-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g 		 5g
25g		 300,-
1170,-
1WLKC2BY Fmoc-Tyr(tBu)-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 170,-
670,-
1WLKC2BV Fmoc-Val-Wang Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-

 net prices in EUR, VAT excluded

 

 

Fmoc-AA-HMPB Synbeads

 

Code Name Qty Price
1MPBC2BA
 		 Fmoc-Ala-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1MPBC2BR-B
 		 Fmoc-Arg(Pbf)-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 390,-
1500,-
1MPBC2BN
 		 Fmoc-Asn(Trt)-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 210,-
850,-
1MPBC2BD
 		 Fmoc-Asp(OtBu)-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 170,-
670,-
1MPBC2BC-B
 		 Fmoc-Cys(Trt)-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 250,-
1000,-
1MPBC2BE
 		 Fmoc-Glu(OtBu)-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 170,-
670,-
1MPBC2BQ
 		 Fmoc-Gln(Trt)-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g

250,-

1000,-
1MPBC2BG
 		 Fmoc-Gly-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g

95,-
370,-
1MPBC2BH Fmoc-His(Trt)-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 185,-
750,-
1MPBC2BI Fmoc-Ile-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1MPBC2BL Fmoc-Leu-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1MPBC2BK
 		 Fmoc-Lys(Boc)-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 170,-
670,-
1MPBC2BM Fmoc-Met-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1MPBC2BF Fmoc-Phe-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1MPBC2BP
 		 Fmoc-Pro-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-
1MPBC2BS Fmoc-Ser(tBu)-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 170,-
670,-
1MPBC2BT Fmoc-Thr(tBu)-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 170,-
670,-
1MPBC2BW Fmoc-Trp(Boc)-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 300,-
1170,-
1MPBC2BY Fmoc-Tyr(tBu)-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g

170,-
670,-
1MPBC2BV Fmoc-Val-HMPB Synbeads
150-300 µm, 0.1-0.4 mmol/g		 5g
25g		 95,-
370,-

 net prices in EUR, VAT excluded

 

 

OLIGOBEADS FEATURES

 

 

 
  • Methacrylate polymers
  • Highly porous structure
  • Optimal particle size distribution
  • High chemical & physical stability
  • Easily scalable on reactors

 

 

Pore size
Å 1200
Pore volume ml/gdry 1.3
Particle size µm 150-300
Surface m2/gdry 25-30
Loading μmol/gdry 10-200
Specific volume ml/gdry 3

 

 

OLIGOBEADS PRODUCT LIST

 

Standard Polymers

 

 

Code Name Qty Price
1AC10BN NH2-Oligobeads
Aminomethyl-methacrylate
150-300 µm, 0.7-1.0 mmol/gdry		 25g
100g
1Kg		 200,-
400,-
2000,-
1AC05BN NH2-Oligobeads
Aminomethyl-methacrylate
150-300 µm, 0.2-05 mmol/gdry
 25g
100g
1Kg		 200,-
400,-
2000,-
1AC02BN NH2-Oligobeads
Aminomethyl-methacrylate
150-300 µm, < 0.2 mmol/gdry
 25g
100g
1Kg		 200,-
400,-
2000,-
1XC07BN COOH-Oligobeads
Carboxyl-methacrylate
150-300 µm, 0.7-0.4 mmol/gdry		 25g
100g
1Kg		 250,-
500,-
2400,-
1XC04BN COOH-Oligobeads
Carboxyl-methacrylate
150-300 µm, 0.4-0.1 mmol/gdry		 25g
100g
1Kg		 250,-
500,-
2400,-
1XC01BN COOH-Oligobeads
Carboxyl-methacrylate
150-300 µm, < 0.1 mmol/gdry
 25g
100g
1Kg		 250,-
500,-
2400,-

net prices in EUR, VAT excluded

 

 

Preloaded Polymers

 

 

Code Name Qty Price
1SC1BT1 DMT-T-Oligobeads
5’-DMT Thymidine
150-300 µm		 5g
25g
100g		 Enquire
1SC1BAB DMT-A n-bz Oligobeads
5’-DMT deoxy Adenosine (n-benzyl)
150-300 µm
 5g
25g
100g		 Enquire
1SC1BAA DMT-A n-acetyl Oligobeads
5’-DMT deoxy Adenosine (n-acetyl)
150-300 µm
 5g
25g
100g		 Enquire
1SC1BAP DMT-A n-PAC Oligobeads
5’-DMT deoxy Adenosine (n-PAC)
150-300 µm		 5g
25g
100g		 Enquire
1SC1BCB DMT-C n-bz Oligobeads
5’-DMT deoxy Cytidine (n-benzyl)
150-300 µm		 5g
25g
100g		  Enquire
1SC1BCA DMT-C n-acetyl Oligobeads
5’-DMT deoxy Cytidine (n-acetyl)
150-300 µm		 5g
25g
100g		  Enquire
1SC1BCP DMT-C n-PAC Oligobeads
5’-DMT deoxy Cytidine (n-PAC)
150-300 µm		 5g
25g
100g		  Enquire
1SC1BCI DMT-C n-ibu Oligobeads
5’-DMT deoxy Cytidine (n-ibu)
150-300 µm		 5g
25g
100g		  Enquire
1SC1BGI DMT-G n-ibu Oligobeads
5’-DMT deoxy Guanosine (n-ibu)
150-300 µm		 5g
25g
100g		  Enquire
1SC1BGP DMT-G n-PAC Oligobeads
5’-DMT deoxy Guanosine (n-PAC)
150-300 µm		 5g
25g
100g		  Enquire
1SC1BGB DMT-G n-tBPAC Oligobeads
5’-DMT deoxy Guanosine (n-tBPAC)
150-300 µm		 5g
25g
100g		  Enquire

net prices in EUR, VAT excluded